Article
A defect of CD16-positive monocytes can occur without disease.
Immunobiology - 1 Feb 2013
Frankenberger Marion, Ekici Arif B, Angstwurm Matthias W, Hoffmann Harald, Hofer Thomas P J, Heimbeck Irene, Meyer Peter, Lohse Peter, Wjst Matthias, Häussinger Karl, Reis André, Ziegler-Heitbrock Loems
Abstract excerpt
The CD16-positive monocytes have been first described in 1988 but to date no selective defect in the number of these cells in blood has been reported. We now describe a family in which three of four siblings lack both CD16-positive monocyte subsets, i.e. the nonclassical and the intermediate monocytes. All three had CD16-positive monocytes of 2 cells/μl or less as compared to 52±18 cells/μl in healthy controls....
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