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Article

Complex effects of flavopiridol on the expression of primary response genes

29 Mar 2012

Abstract excerpt

BACKGROUND: The Positive Transcription Elongation Factor b (P-TEFb) is a complex of Cyclin Dependent Kinase 9 (CDK9) with either cyclins T1, T2 or K. The complex phosphorylates the C-Terminal Domain of RNA polymerase II (RNAPII) and negative elongation factors, stimulating productive elongation by RNAPII, which is paused after initiation. P-TEFb is recruited downstream of the promoters of many genes, including...

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PMID: 22458775
DOI: 10.1186/1747-1028-7-11

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