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Article

Human FKBP5 Negatively Regulates Transcription through Inhibition of P-TEFb Complex Formation

15 Nov 2021

Abstract excerpt

Although a large number of recent studies indicate strong association of FKBP5 (aka FKBP51) functions with various stress-related psychiatric disorders, the overall mechanisms are poorly understood. Beyond a few studies indicating its functions in regulating glucocorticoid receptor, and AKT signaling pathways, other functional roles (if any) are unclear. Here, we report an antiproliferative role of human FKBP5...

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PMID: 34780285
DOI: 10.1128/mcb.00344-21

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