Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Functional Role of an Interleukin 6-inducible CDK9·STAT3 Complex in Human γ-Fibrinogen Gene Expression

24 Oct 2007

Abstract excerpt

The signal transducer and activator of transcription 3 (STAT3) is an IL-6-inducible transcription factor that mediates the hepatic acute phase response (APR). Using gamma-fibrinogen (FBG) as a model of the APR, we investigated the requirement of an IL-6-inducible complex of STAT3 with cyclin-dependent kinase 9 (CDK9) on gamma-FBG expression in HepG2 hepatocarcinoma cells. IL-6 induces rapid nuclear translocation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Cytokine Signaling Pathways and Interactions
Share to HER2/EGFR in Cancer Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17956865
DOI: 10.1074/jbc.m706458200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Functional Role of an Interleukin 6-inducible CDK9·STAT3 Complex in Human γ-Fibrinogen Gene ExpressionPMID 17956865Read ↗

CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene lociSemantic proximity Read ↗

Characterization of the IL-6 Responsive Elements in the γ Fibrinogen Gene PromoterSemantic proximity Read ↗

Direct Association of STAT3 with the IFNAR-1 Chain of the Human Type I Interferon ReceptorSemantic proximity Read ↗

Protein kinase C delta associates with the interleukin-6 receptor subunit glycoprotein (gp) 130 via Stat3 and enhances Stat3-gp130 interaction.Semantic proximity Read ↗

Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 functionSemantic proximity Read ↗

STAT3 Participates in Transcriptional Activation of the C-reactive Protein Gene by Interleukin-6Semantic proximity Read ↗

Chromatin Dynamics of Gene Activation and Repression in Response to Interferon α (IFNα) Reveal New Roles for Phosphorylated and Unphosphorylated Forms of the Transcription Factor STAT2Semantic proximity Read ↗

Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseasesSemantic proximity Read ↗

The Tumor Suppressor Interferon Regulatory Factor 1 Interferes with SP1 Activation to Repress the Human CDK2 PromoterSemantic proximity Read ↗

Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongationSemantic proximity Read ↗

Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distributionSemantic proximity Read ↗

Glucocorticoids Increase Interleukin–6–Dependent Gene Induction by Interfering With the Expression of the Suppressor of Cytokine Signaling 3 Feedback InhibitorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.