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Article

RhoA as a Mediator of Clinically Relevant Androgen Action in Prostate Cancer Cells

29 Mar 2012

Abstract excerpt

Recently, we have identified serum response factor (SRF) as a mediator of clinically relevant androgen receptor (AR) action in prostate cancer (PCa). Genes that rely on SRF for androgen responsiveness represent a small fraction of androgen-regulated genes, but distinguish benign from malignant prostate, correlate with aggressive disease, and are associated with biochemical recurrence. Thus, understanding the...

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Identifiers

PMID: 22456196
DOI: 10.1210/me.2011-1130

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