The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: the CHARISMA genetics study.

doi:10.1093/eurheartj/ehs059

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Article

The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: the CHARISMA genetics study.

European heart journal - 1 Sept 2012

Bhatt Deepak L, Paré Guillaume, Eikelboom John W, Simonsen Katy L, Emison Eileen S, Fox Keith A A, Steg Ph Gabriel, Montalescot Gilles, Bhakta Nihar, Hacke Werner, Flather Marcus D, Mak Koon-Hou, Cacoub Patrice, Creager Mark A, Berger Peter B, Steinhubl Steven R, Murugesan Gurunathan, Mehta Shamir R, Kottke-Marchant Kandice, Lincoff A Michael, Topol Eric J

Abstract excerpt

AIMS: Clinical trials have established the value of clopidogrel therapy in a wide spectrum of patients with cardiovascular diseases. Both loss- and gain-of-function single nucleotide variants of CYP2C19 genes have been identified that affect clopidogrel metabolism and anti-platelet response. We sought to determine the impact of CYP2C19 polymorphisms on ischaemic and bleeding events. METHODS AND RESULTS: A subset...

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PMID: 22450429
DOI: 10.1093/eurheartj/ehs059

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