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Modelling the Regulation of Thermal Adaptation in Candida albicans, a Major Fungal Pathogen of Humans

20 Mar 2012

Abstract excerpt

Eukaryotic cells have evolved mechanisms to sense and adapt to dynamic environmental changes. Adaptation to thermal insults, in particular, is essential for their survival. The major fungal pathogen of humans, Candida albicans, is obligately associated with warm-blooded animals and hence occupies thermally buffered niches. Yet during its evolution in the host it has retained a bona fide heat shock response whilst...

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PMID: 22448221
DOI: 10.1371/journal.pone.0032467

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