Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans.

PloS one - 1 Jan 2012

Mayer François L, Wilson Duncan, Jacobsen Ilse D, Miramón Pedro, Slesiona Silvia, Bohovych Iryna M, Brown Alistair J P, Hube Bernhard

Abstract excerpt

Small heat shock proteins (sHsps) have multiple cellular functions. However, the biological function of sHsps in pathogenic microorganisms is largely unknown. In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans. Using a reverse genetics approach we demonstrate the importance of Hsp21 for resistance of C. albicans to specific stresses, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Candida albicans
Share to Candidiasis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chick Embryo

Share to Human Umbilical Vein Endothelial Cells

Share to Mitogen-Activated Protein Kinase 3

Share to Neutrophils

Share to Trehalose

Share to Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 22685587
DOI: 10.1371/journal.pone.0038584
PMCID: PMC3369842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans.PMID 22685587Read ↗

Functional characterization of the small heat shock protein Hsp12p from Candida albicans.Semantic proximity Read ↗

The two‐component response regulator Skn7 belongs to a network of transcription factors regulating morphogenesis in Candida albicans and independently limits morphogenesis‐induced ROS accumulationSemantic proximity Read ↗

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicansSemantic proximity Read ↗

Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicansSemantic proximity Read ↗

Expansion of the functional genomics GRACE library reveals genes relevant for temperature-dependent fitness in Candida albicans.Semantic proximity Read ↗

Roles of Hsp90 in Candida albicans morphogenesis and virulenceSemantic proximity Read ↗

Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformansSemantic proximity Read ↗

Uncovering cellular circuitry controlling temperature-dependent fungal morphogenesisSemantic proximity Read ↗

The Hsp90 Chaperone Network Modulates Candida Virulence TraitsSemantic proximity Read ↗

The small heat shock protein Hsp27: Present understanding and future prospects.Semantic proximity Read ↗

Systematic analysis of the Candida albicans kinome reveals environmentally contingent protein kinase-mediated regulation of filamentation and biofilm formation in vitro and in vivoSemantic proximity Read ↗

Roles of P-body factors in Candida albicans filamentation and stress responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.