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Article

Mathematical modeling of the Candida albicans yeast to hyphal transition reveals novel control strategies.

PLoS computational biology - 1 Mar 2021

Wooten David J, Zañudo Jorge Gómez Tejeda, Murrugarra David, Perry Austin M, Dongari-Bagtzoglou Anna, Laubenbacher Reinhard, Nobile Clarissa J, Albert Réka

Abstract excerpt

Candida albicans, an opportunistic fungal pathogen, is a significant cause of human infections, particularly in immunocompromised individuals. Phenotypic plasticity between two morphological phenotypes, yeast and hyphae, is a key mechanism by which C. albicans can thrive in many microenvironments and cause disease in the host. Understanding the decision points and key driver genes controlling this important...

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Share to Antifungal resistance and susceptibility
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33780439
DOI: 10.1371/journal.pcbi.1008690
PMCID: PMC8031856

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