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Article

Force-induced craniosynostosis via paracrine signaling in the murine sagittal suture.

The Journal of craniofacial surgery - 1 Mar 2012

Oppenheimer Adam J, Rhee Samuel T, Goldstein Steven A, Buchman Steven R

Abstract excerpt

INTRODUCTION: The role of genetic phenomena has been given central importance in the development of craniosynostosis. Proponents have dismissed the role of force as a key etiologic factor. Nonetheless, compressive forces on the developing calvarium have been shown to result in premature suture fusion. The purpose of this study was to determine whether cyclical loading of the murine calvarium could induce suture...

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Identifiers

PMID: 22446418
DOI: 10.1097/SCS.0b013e318241db3e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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