Article
Medical treatment of craniosynostosis: recombinant Noggin inhibits coronal suture closure in the rat craniosynostosis model.
Orthodontics & craniofacial research - 1 Aug 2009
Shen K, Krakora S M, Cunningham M, Singh M, Wang X, Hu F Z, Post J C, Ehrlich G D
Abstract excerpt
INTRODUCTION - The mechanisms underlying craniosynostosis remains unknown. However, mutations in FGFR2 are associated with craniosynostotic syndromes. We previously compared gene expression patterns of patent and synostosing coronal sutures in the nude rat and demonstrated down regulation of Noggin in synostosing sutures. Noggin expression is also suppressed by FGF2 and constitutive FGFR2 signaling [Warren et al....
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