Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans.

doi:10.1016/j.mad.2012.03.003

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Article

Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans.

Mechanisms of ageing and development - 1 May 2012

Valentini Sara, Cabreiro Filipe, Ackerman Daniel, Alam Muhammed M, Kunze Micha B A, Kay Christopher W M, Gems David

Abstract excerpt

Iron-catalyzed generation of free radicals leads to molecular damage in vivo, and has been proposed to contribute to organismal ageing. Here we investigate the role of free iron in ageing in the nematode Caenorhabditis elegans. Media supplementation with Fe(III) increased free iron levels in vivo, as detected by continuous-wave electron paramagnetic resonance spectroscopy and elevated expression of the...

Topics

Aging
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cells, Cultured
Deferoxamine
Ferritins
Iron
Longevity
Mutation
Oxidation-Reduction
Oxidative Stress
Receptor, IGF Type 1

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Receptor, Insulin

Siderophores

Signal Transduction

tert-Butylhydroperoxide

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Identifiers

PMID: 22445852
DOI: 10.1016/j.mad.2012.03.003
PMCID: PMC3449239

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