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Article

Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1.

Neurobiology of aging - 1 Dec 2012

Gui Ya-Xing, Wang Xin-Yi, Kang Wen-Yan, Zhang Ying-Jie, Zhang Yu, Zhou Yong, Quinn Thomas J, Liu Jun, Chen Sheng-Di

Abstract excerpt

Compounding evidence suggests that alpha-synuclein (SNCA) plays an important role in the pathogenesis of Parkinson's disease (PD) by inducing neurotoxicity. Mitochondria are highly dynamic organelles that undergo fusion and fission processes, the imbalance of which has been viewed as a key trigger for PD. However, the underlying relationship between SNCA and mitochondrial dynamics remains unclear. This study...

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Source

Identifiers

PMID: 22445325
DOI: 10.1016/j.neurobiolaging.2012.02.001

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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