M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.

doi:10.1172/jci.insight.91868

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.

JCI insight - 6 Apr 2017

Cole Suzanne L, Dunning Jake, Kok Wai Ling, Benam Kambez Hajipouran, Benlahrech Adel, Repapi Emmanouela, Martinez Fernando O, Drumright Lydia, Powell Timothy J, Bennett Michael, Elderfield Ruth, Thomas Catherine, Dong Tao, McCauley John, Liew Foo Y, Taylor Stephen, Zambon Maria, Barclay Wendy, Cerundolo Vincenzo, Openshaw Peter J, McMichael Andrew J, Ho Ling-Pei

Abstract excerpt

In each influenza season, a distinct group of young, otherwise healthy individuals with no risk factors succumbs to life-threatening infection. To better understand the cause for this, we analyzed a broad range of immune responses in blood from a unique cohort of patients, comprising previously healthy individuals hospitalized with and without respiratory failure during one influenza season, and infected with one...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Influenza A Virus, H5N1 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza, Human

Share to Lung

Share to Macrophages

Share to Mice, Inbred C57BL

Share to Monocytes

Share to Tumor Necrosis Factor-alpha

Share to Viral Load

Source

Open in PubMed Open full text

Identifiers

PMID: 28405622
DOI: 10.1172/jci.insight.91868
PMCID: PMC5374077

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.PMID 28405622Read ↗

SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating monocytes and alterations in both dendritic cell and monocyte subsetsSemantic proximity Read ↗

Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infectionSemantic proximity Read ↗

Classical Monocytes-Low Expressing Hla-Dr is Associated with Higher Mortality Rate in Sars-Cov-2+ Young Patients with Severe PneumoniaSemantic proximity Read ↗

Innate Immunity to H5N1 Influenza Viruses in HumansSemantic proximity Read ↗

Heterotypic Influenza Infections Mitigate Susceptibility to Secondary Bacterial InfectionSemantic proximity Read ↗

Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophagesSemantic proximity Read ↗

Heterogeneity of monocyte subsets and susceptibility to influenza virus contribute to inter-population variability of protective immunitySemantic proximity Read ↗

Type-1 IFN primed monocytes in pathogenesis of idiopathic pulmonary fibrosisSemantic proximity Read ↗

Monocyte production of C1q potentiates CD8 <sup>+</sup> T cell effector function following respiratory viral infectionSemantic proximity Read ↗

Decrease of Non-Classical and Intermediate Monocyte Subsets in Severe Acute SARS-CoV-2 Infection.Semantic proximity Read ↗

The role of polymorphisms in host immune genes in determining the severity of respiratory illness caused by pandemic H1N1 influenza.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.