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Differential onset of apoptosis in influenza A virus H5N1- and H1N1-infected human blood macrophages

20 Mar 2007

Abstract excerpt

Pathogenesis of the highly pathogenic avian influenza virus A/Hong Kong/483/97 (H5N1/97) remains to be investigated. It was demonstrated recently that H5N1 dysregulation of proinflammatory cytokines in human macrophages is a p38-kinase-dependent process. The results indicated that macrophages may play a role in disease severity. To investigate cellular responses to H5N1 infection further, apoptosis and its...

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PMID: 17374772
DOI: 10.1099/vir.0.82423-0

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