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Influenza A Viruses Target Type II Pneumocytes in the Human Lung

24 Jul 2012

Abstract excerpt

BACKGROUND: Highly pathogenic avian H5N1 influenza viruses preferentially infect alveolar type II pneumocytes in human lung. However, it is unknown whether this cellular tropism contributes to high viral virulence because the primary target cells of other influenza viruses have not been systematically studied. METHODS: We provide the first comparison of the replication, tropism, and cytokine induction of human,...

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PMID: 22829640
DOI: 10.1093/infdis/jis455

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