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Article

ARIEL and AMELIA: testing for an accumulation of rare variants using next-generation sequencing data.

Human heredity - 1 Jan 2012

Asimit Jennifer L, Day-Williams Aaron G, Morris Andrew P, Zeggini Eleftheria

Abstract excerpt

OBJECTIVES: There is increasing evidence that rare variants play a role in some complex traits, but their analysis is not straightforward. Locus-based tests become necessary due to low power in rare variant single-point association analyses. In addition, variant quality scores are available for s...

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Identifiers

PMID: 22441326
DOI: 10.1159/000336982
PMCID: PMC3477640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22441326-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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