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Article

Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini-exome data.

Genetic epidemiology - 1 Jan 2011

Bailey-Wilson Joan E, Brennan Jennifer S, Bull Shelley B, Culverhouse Robert, Kim Yoonhee, Jiang Yuan, Jung Jeesun, Li Qing, Lamina Claudia, Liu Ying, Mägi Reedik, Niu Yue S, Simpson Claire L, Wang Libo, Yilmaz Yildiz E, Zhang Heping, Zhang Zhaogong

Abstract excerpt

Group 14 of Genetic Analysis Workshop 17 examined several issues related to analysis of complex traits using DNA sequence data. These issues included novel methods for analyzing rare genetic variants in an aggregated manner (often termed collapsing rare variants), evaluation of various study designs to increase power to detect effects of rare variants, and the use of machine learning approaches to model highly...

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PMID: 22128066
DOI: 10.1002/gepi.20657
PMCID: PMC3360949

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