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Article

Role of FOXP3 gene polymorphism in the susceptibility to Tunisian endemic Pemphigus Foliaceus.

Immunology letters - 1 Apr 2017

Ben Jmaa Mariem, Abida Olfa, Bahloul Emna, Toumi Amina, Khlif Sana, Fakhfakh Raouia, Elloumi Nesrine, Sellami Khadija, Masmoudi Abderrahmen, Turki Hamida, Masmoudi Hatem

Abstract excerpt

OBJECTIVE: Forkhead box P3 (FOXP3) is an essential and crucial transcription factor of regulatory T-cells. Genetic polymorphisms in the promoter region of FOXP3 gene may alter the gene expression level and, therefore, contribute to several autoimmune diseases susceptibility. We aimed to investigate the possible role of genetic variants of four SNPs (rs3761547, rs3761548, rs3761549 and rs2294021) and a (GT)n...

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Source

Identifiers

PMID: 28216259
DOI: 10.1016/j.imlet.2017.02.005

Genes

FOXP3

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