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Article

Geometry, epistasis, and developmental patterning.

Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2012

Corson Francis, Siggia Eric Dean

Abstract excerpt

Developmental signaling networks are composed of dozens of components whose interactions are very difficult to quantify in an embryo. Geometric reasoning enumerates a discrete hierarchy of phenotypic models with a few composite variables whose parameters may be defined by in vivo data. Vulval development in the nematode Caenorhabditis elegans is a classic model for the integration of two signaling pathways;...

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Identifiers

PMID: 22434912
DOI: 10.1073/pnas.1201505109
PMCID: PMC3326455

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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