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Article

On the evolution and development of morphological complexity: A view from gene regulatory networks.

PLoS computational biology - 1 Feb 2021

Hagolani Pascal F, Zimm Roland, Vroomans Renske, Salazar-Ciudad Isaac

Abstract excerpt

How does morphological complexity evolve? This study suggests that the likelihood of mutations increasing phenotypic complexity becomes smaller when the phenotype itself is complex. In addition, the complexity of the genotype-phenotype map (GPM) also increases with the phenotypic complexity. We show that complex GPMs and the above mutational asymmetry are inevitable consequences of how genes need to be wired in...

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Identifiers

PMID: 33626036
DOI: 10.1371/journal.pcbi.1008570
PMCID: PMC7939363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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