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Article

Down-regulation of Fer induces ROS levels accompanied by ATM and p53 activation in colon carcinoma cells.

Cellular signalling - 1 Jul 2012

Makovski Adar, Yaffe Etai, Shpungin Sally, Nir Uri

Abstract excerpt

Fer is an intracellular tyrosine kinase which resides in both the cytoplasm and nucleus of mammalian cells. This kinase was also found in all malignant cell-lines analyzed and was shown to support cell-cycle progression in cancer cells. Herein we show that knock-down of Fer, both, impairs cell-cycle progression and imposes programmed cell death in colon carcinoma (CC) cells. The cell-cycle arrest and apoptotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22434045
DOI: 10.1016/j.cellsig.2012.03.004

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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