Article
Inhibition of protein kinase C-alpha isoform enhances the P-glycoprotein expression and the survival of LoVo human colon adenocarcinoma cells to doxorubicin exposure.
British journal of cancer - 1 Nov 1998
La Porta C A, Dolfini E, Comolli R
Abstract excerpt
The aim of the present paper was to analyse the effect of long-term inhibitory treatment, for at least 7 days, of individual protein kinase C (PKC) isoforms on the survival of LoVo human colon adenocarcinoma cells to doxorubicin exposure. The treatment for 2 h, after plating the cells, and after...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adenocarcinoma
- Antineoplastic Agents
- Cell Survival
- Colonic Neoplasms
- Doxorubicin
- Drug Resistance, Neoplasm
- Gene Expression Regulation, Neoplastic
- Humans
- Isoenzymes
- Phenotype
- Protein Kinase C
- Tumor Cells, Cultured