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Article

A basal cell defect promotes budding of prostatic intraepithelial neoplasia.

Journal of cell science - 1 Jan 2017

Wang Mengdie, Nagle Raymond B, Knudsen Beatrice S, Rogers Gregory C, Cress Anne E

Abstract excerpt

Basal cells in a simple secretory epithelium adhere to the extracellular matrix (ECM), providing contextual cues for ordered repopulation of the luminal cell layer. Early high-grade prostatic intraepithelial neoplasia (HG-PIN) tissue has enlarged nuclei and nucleoli, luminal layer expansion and genomic instability. Additional HG-PIN markers include loss of α6β4 integrin or its ligand laminin-332, and budding of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27609833
DOI: 10.1242/jcs.188177
PMCID: PMC5394777

Genes

KLK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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