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Runx1 and Runx2 cooperate during sternal morphogenesis

25 Feb 2010

Abstract excerpt

Chondrocyte differentiation is strictly regulated by various transcription factors, including Runx2 and Runx3; however, the physiological role of Runx1 in chondrocyte differentiation remains unknown. To examine the role of Runx1, we generated mesenchymal-cell-specific and chondrocyte-specific Runx1-deficient mice [Prx1 Runx1(f/f) mice and alpha1(II) Runx1(f/f) mice, respectively] to circumvent the embryonic...

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PMID: 20181744
DOI: 10.1242/dev.045005

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