ARF suppresses hepatic vascular neoplasia in a carcinogen-exposed murine model.

Abstract excerpt

Hepatic haemangiosarcoma is a deadly malignancy whose aetiology remains poorly understood. Inactivation of the CDKN2A locus, which houses the ARF and p16(INK4a) tumour suppressor genes, is a common event in haemangiosarcoma patients, but the precise role of ARF in vascular tumourigenesis is unknown. To determine the extent to which ARF suppresses vascular neoplasia, we examined the incidence of hepatic vascular...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Carcinogens
• Share to Cell Transformation, Neoplastic
• Share to Cyclin-Dependent Kinase Inhibitor p16