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Article

The risks of breast and ovarian cancer associated with the Ashkenazi Jewish founder allele BRCA2 6174delT.

Clinical genetics - 1 Mar 2022

Finch Amy, Metcalfe Kelly, Akbari Mohammad, Friedman Eitan, Tung Nadine, Rosen Barry, Eisen Andrea, Karlan Beth, Foulkes William, Neuhausen Susan L, Senter Leigha, McKinnon Wendy, Elser Christine, Sun Ping, Narod Steven A

Abstract excerpt

Approximately 1% of the Ashkenazi Jewish population carries the BRCA2 6174delT (c.5946del) pathogenic variant. It is important to have accurate knowledge of the risks of breast and ovarian cancer associated with this specific variant so that women may be counseled accordingly. In this prospective study, we estimated the risks of breast and ovarian cancer associated with the 6174delT variant compared with the...

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PMID: 34897671
DOI: 10.1111/cge.14098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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