Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Balance of human choline kinase isoforms is critical for cell cycle regulation

19 Mar 2012

Abstract excerpt

The enzyme choline kinase (CK), which catalyzes the phosphorylation of choline to phosphorylcholine in the presence of ATP, has an essential role in the biosynthesis of phosphatidylcholine, the major constituent of all mammalian cell membranes. CK is encoded by two separate genes expressing the three isoforms CKα1, CKα2 and CKβ that are active as homodimeric or heterodimeric species. Metabolic changes observed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22429312
DOI: 10.1111/j.1742-4658.2012.08573.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Balance of human choline kinase isoforms is critical for cell cycle regulationPMID 22429312Read ↗

The PD-L1 metabolic interactome intersects with choline metabolism and inflammationSemantic proximity Read ↗

Choline kinase and its functionThis paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

Involvement of human choline kinase alpha and beta in carcinogenesis: A different role in lipid metabolism and biological functionsSemantic proximity Read ↗

Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma.Semantic proximity Read ↗

Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancersSemantic proximity Read ↗

CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disordersSemantic proximity Read ↗

Exploring the CK2 Paradox: Restless, Dangerous, DispensableSemantic proximity Read ↗

Protein kinase CK2: a potential therapeutic target for diverse human diseases.Semantic proximity Read ↗

Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma ManagementSemantic proximity Read ↗

Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategySemantic proximity Read ↗

Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cellsSemantic proximity Read ↗

Generation and validation of an anti-human PANK3 mouse monoclonal antibodySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.