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Article

Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma.

Oncotarget - 10 May 2015

Granata Anna, Nicoletti Roberta, Perego Paola, Iorio Egidio, Krishnamachary Balaji, Benigni Fabio, Ricci Alessandro, Podo Franca, Bhujwalla Zaver M, Canevari Silvana, Bagnoli Marina, Mezzanzanica Delia

Abstract excerpt

Epithelial Ovarian Cancer (EOC) "cholinic phenotype", characterized by increased intracellular phosphocholine content sustained by over-expression/activity of choline kinase-alpha (ChoKα/CHKA), is a metabolic cellular reprogramming involved in chemoresistance with still unknown mechanisms.By stable CHKA silencing and global metabolic profiling here we demonstrate that CHKA knockdown hampers growth capability of...

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Identifiers

PMID: 25796169
DOI: 10.18632/oncotarget.3589
PMCID: PMC4484451

Genes

CHKA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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