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Article

Keratinocyte growth factor induces gene expression signature associated with suppression of malignant phenotype of cutaneous squamous carcinoma cells.

PloS one - 1 Jan 2012

Toriseva Mervi, Ala-aho Risto, Peltonen Sirkku, Peltonen Juha, Grénman Reidar, Kähäri Veli-Matti

Abstract excerpt

Keratinocyte growth factor (KGF, fibroblast growth factor-7) is a fibroblast-derived mitogen, which stimulates proliferation of epithelial cells. The expression of KGF by dermal fibroblasts is induced following injury and it promotes wound repair. However, the role of KGF in cutaneous carcinogenesis and cancer progression is not known. We have examined the role of KGF in progression of squamous cell carcinoma...

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Source

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Identifiers

PMID: 22427941
DOI: 10.1371/journal.pone.0033041
PMCID: PMC3299721

Genes

CXCL10
DUSP4
DUSP6
IGFBP3
MATN2
MMP13
PHLDA1
SPRY4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Keratinocyte growth factor induces gene expression signature associated with suppression of malignant phenotype of cutaneous squamous carcinoma cells.PMID 22427941Read ↗

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