Article
A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site.
The Journal of biological chemistry - 25 Feb 1992
Bajt M L, Ginsberg M H, Frelinger A L, Berndt M C, Loftus J C
Abstract excerpt
This work characterizes a mutant integrin alpha IIb beta 3 (glycoprotein (GP) IIb-IIIa) from a thrombasthenic patient, ET, whose platelets fail to aggregate in response to stimuli. The nature of defect was defined by the reduced ability of synthetic peptide ligands, corresponding to the carboxyl terminus of the fibrinogen gamma chain (gamma 402-411) and Arg-Gly-Asp (RGD), to increase the binding of the...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Binding Sites
- CHO Cells
- Chromatography, Affinity
- Cricetinae
- DNA
- Fibrinogen