A Glanzmann thrombasthenia-like phenotype caused by a defect in inside-out signaling through the integrin alpha(IIb)beta3.

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Article

A Glanzmann thrombasthenia-like phenotype caused by a defect in inside-out signaling through the integrin alpha(IIb)beta3.

Thrombosis and haemostasis - 1 Nov 1998

Tomiyama Y, Shiraga M, Kinoshita S, Ambo H, Kurata Y, Matsuzawa Y, Kunicki T J

Abstract excerpt

Activation of the platelet integrin alpha(IIb)beta3, an essential step in platelet aggregation, is regulated by intracellular signal pathways (inside-out signaling). In this study, we characterize a 35-year-old Japanese female, HM, with a life-long history of mucocutaneous bleeding. HM showed a G...

Topics

Adult
Antibodies, Monoclonal
Blood Platelets
Blood Proteins
Chymotrypsin
DNA, Complementary
Female
Fibrinogen
Hemorrhagic Disorders
Humans
Myosin Light Chains
Oligopeptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Phosphoproteins

Phosphorylation

Platelet Aggregation

Platelet Glycoprotein GPIIb-IIIa Complex

Protein Processing, Post-Translational

Source

Open in PubMed

Identifiers

PMID: 9843164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9843164-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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