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Article

[Relationship between the acquired multi-drug resistance of human large cell lung cancer cell line NCI-H460 by cisplatin selection and p53 mutation].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases - 1 Feb 2005

Wang Tao, Xu Jun, Zhong Nan-shan

Abstract excerpt

OBJECTIVE: To explore the role of p53 mutation in the development of acquired multi-drug resistance during lung cancer chemotherapy. METHODS: A resistance large cell lung carcinoma cell line (H460/DDP) was established by high dose (50 micromol/L) cisplatin intermittent selection from its parental cell NCI-H460 that had wild type p53 (wtp53). Several multi-drug resistant proteins (MRP) including lung relative...

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PMID: 15854392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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