Favorable effect of the combination of vinorelbine and dihydropyrimidine dehydrogenase‑inhibitory fluoropyrimidine in EGFR‑mutated lung adenocarcinoma: retrospective and in vitro studies.

doi:10.3892/ijo.2015.2815

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Article

Favorable effect of the combination of vinorelbine and dihydropyrimidine dehydrogenase‑inhibitory fluoropyrimidine in EGFR‑mutated lung adenocarcinoma: retrospective and in vitro studies.

International journal of oncology - 1 Mar 2015

Izumi Hiroki, Touge Hirokazu, Igishi Tadashi, Makino Haruhiko, Nishii-Ito Shizuka, Takata Miyako, Nakazaki Hirofumi, Ueda Yasuto, Matsumoto Shingo, Kodani Masahiro, Kurai Jun, Takeda Kenichi, Sakamoto Tomohiro, Yanai Masaaki, Tanaka Natsumi, Nirodi Chaitanya S, Shimizu Eiji

Abstract excerpt

Although cytotoxic chemotherapy is essential in epidermal growth factor receptor (EGFR)‑mutated non‑small cell lung cancer (NSCLC), it is unclear which regimen is most effective. We retrospectively compared the efficacy of standard platinum‑based chemotherapy with that of combination chemotherapy using vinorelbine (VNR) plus dihydropyrimidine dehydrogenase‑inhibitory fluoropyrimidine (DIF) in EGFR‑mutated lung...

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PMID: 25573239
DOI: 10.3892/ijo.2015.2815
PMCID: PMC4324589

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EGFR

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