Regulation of the dnaQ gene of Escherichia coli in mutants expressing the SOS regulon constitutively.

Abstract excerpt

Current models for the mechanism of SOS mutagenesis in E. coli propose the involvement of a new or modified DNA polymerase III holoenzyme in error-prone replicative bypass of bulky DNA lesions assuming an inhibited or excluded 3'----5' proofreading exonuclease function of DNA polymerase. By promotor fusion to galK, gene fusion to lacZ and Sl analysis the in vivo regulation of dnaQ coding the proofreading subunit...

Topics

• DNA Polymerase III
• Escherichia coli
• Gene Expression Regulation, Bacterial
• Genes, Bacterial
• Mutation
• SOS Response, Genetics
• Transcription, Genetic