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Article

Anti-integrin monoclonal antibodies

12 Nov 2009

Abstract excerpt

Integrins are a family of 24 heterodimeric transmembrane receptors that support cell-cell and cell-ECM (extracellular matrix) interactions in a multitude of physiological and disease situations (Humphries, 2000; Hynes, 2002). Adhesion that is mediated by integrins is controlled dynamically to allow cell positioning and migration and to prevent abnormal trafficking and anchorage. Integrin signalling in response to...

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PMID: 19910492
DOI: 10.1242/jcs.056770

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