Article
Anti-integrin monoclonal antibodies
12 Nov 2009
Abstract excerpt
Integrins are a family of 24 heterodimeric transmembrane receptors that support cell-cell and cell-ECM (extracellular matrix) interactions in a multitude of physiological and disease situations (Humphries, 2000; Hynes, 2002). Adhesion that is mediated by integrins is controlled dynamically to allow cell positioning and migration and to prevent abnormal trafficking and anchorage. Integrin signalling in response to...