Article
A meta-analysis of the relationship between FGFR3 and TP53 mutations in bladder cancer.
PloS one - 1 Jan 2012
Neuzillet Yann, Paoletti Xavier, Ouerhani Slah, Mongiat-Artus Pierre, Soliman Hany, de The Hugues, Sibony Mathilde, Denoux Yves, Molinie Vincent, Herault Aurélie, Lepage May-Linda, Maille Pascale, Renou Audrey, Vordos Dimitri, Abbou Claude-Clément, Bakkar Ashraf, Asselain Bernard, Kourda Nadia, El Gaaied Amel, Leroy Karen, Laplanche Agnès, Benhamou Simone, Lebret Thierry, Allory Yves, Radvanyi François
Abstract excerpt
TP53 and FGFR3 mutations are the most common mutations in bladder cancers. FGFR3 mutations are most frequent in low-grade low-stage tumours, whereas TP53 mutations are most frequent in high-grade high-stage tumours. Several studies have reported FGFR3 and TP53 mutations to be mutually exclusive events, whereas others have reported them to be independent. We carried out a meta-analysis of published findings for...
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