Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IDH mutation and neuroglial developmental features define clinically distinct subclasses of lower grade diffuse astrocytic glioma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2012

Gorovets Daniel, Kannan Kasthuri, Shen Ronglai, Kastenhuber Edward R, Islamdoust Nasrin, Campos Carl, Pentsova Elena, Heguy Adriana, Jhanwar Suresh C, Mellinghoff Ingo K, Chan Timothy A, Huse Jason T

Abstract excerpt

PURPOSE: Diffuse gliomas represent the most prevalent class of primary brain tumor. Despite significant recent advances in the understanding of glioblastoma [World Health Organization (WHO) IV], its most malignant subtype, lower grade (WHO II and III) glioma variants remain comparatively understudied, especially in light of their notable clinical heterogeneity. Accordingly, we sought to identify and characterize...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to Neoplasm Grading

Share to Oligodendroglia

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Share to Survival Rate

Source

Identifiers

PMID: 22415316
DOI: 10.1158/1078-0432.CCR-11-2977

Genes

EGFR
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IDH mutation and neuroglial developmental features define clinically distinct subclasses of lower grade diffuse astrocytic glioma.PMID 22415316Read ↗

The Evolving Role of Molecular Markers in the Diagnosis and Management of Diffuse GliomaSemantic proximity Read ↗

Diagnostic utility of genetic alterations in distinguishing IDH-wildtype glioblastoma from lower-grade gliomas: Insight from next-generation sequencing analysis of 479 cases.Semantic proximity Read ↗

Genomic profiling of lower-grade gliomas uncovers cohesive disease groups: implications for diagnosis and treatment.Semantic proximity Read ↗

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.Semantic proximity Read ↗

Molecular subclassification of diffuse gliomas: Seeing order in the chaosSemantic proximity Read ↗

Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastomaSemantic proximity Read ↗

Beyond IDH-Mutation: Emerging Molecular Diagnostic and Prognostic Features in Adult Diffuse GliomasSemantic proximity Read ↗

IDH-wildtype lower-grade diffuse gliomas: the importance of histological grade and molecular assessment for prognostic stratification.Semantic proximity Read ↗

Prognostic relevance of genetic alterations in diffuse lower-grade gliomas.Semantic proximity Read ↗

IDH-mutant diffuse gliomas: tips and tricks in the era of genomic tumor classification.Semantic proximity Read ↗

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.Semantic proximity Read ↗

Molecular signatures classify astrocytic gliomas by IDH1 mutation status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.