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Article

A CYP26B1 polymorphism enhances retinoic acid catabolism and may aggravate atherosclerosis.

Molecular medicine (Cambridge, Mass.) - 9 May 2012

Krivospitskaya Olesya, Elmabsout Ali Ateia, Sundman Eva, Söderström Leif A, Ovchinnikova Olga, Gidlöf Andreas C, Scherbak Nikolai, Norata Giuseppe Danilo, Samnegård Ann, Törmä Hans, Abdel-Halim Samy M, Jansson Jan-Håkan, Eriksson Per, Sirsjö Allan, Olofsson Peder S

Abstract excerpt

All-trans retinoic acid, controlled by cytochrome P450, family 26 (CYP26) enzymes, potentially has beneficial effects in atherosclerosis treatment. This study investigates CYP26 subfamily B, polypeptide 1 (CYP26B1) in atherosclerosis and the effects of a genetic polymorphism in CYP26B1 on retinoid catabolism. We found that CYP26B1 mRNA was induced by retinoic acid in human atherosclerotic arteries, and CYP26B1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22415012
DOI: 10.2119/molmed.2012.00094
PMCID: PMC3388133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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