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Article

Association between P478S polymorphism of the filaggrin gene and risk of psoriasis in a Chinese population in Taiwan.

Archives of dermatological research - 1 Mar 2008

Chang Ya-Ching, Wu Wei-Ming, Chen Chien-Hsun, Hu Chiao-Feng, Hsu Lung-An

Abstract excerpt

Abnormal keratinocyte terminal differentiation is one of the important characteristics of psoriatic lesions. Filaggrin (FLG) is a key protein that facilitates the terminal differentiation of the epidermis. Thus, FLG genetic variants may modify the risk of psoriasis. In total, 314 patients with psoriasis and 611 control subjects were analyzed for the presence of FLG R501X, 2282del4 mutations, and P478S...

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Source

Identifiers

PMID: 18193244
DOI: 10.1007/s00403-007-0821-2

Genes

FLG

Variants

rs11584340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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