Article
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.
Science translational medicine - 16 Feb 2011
Guevara-Aguirre Jaime, Balasubramanian Priya, Guevara-Aguirre Marco, Wei Min, Madia Federica, Cheng Chia-Wei, Hwang David, Martin-Montalvo Alejandro, Saavedra Jannette, Ingles Sue, de Cabo Rafael, Cohen Pinchas, Longo Valter D
Abstract excerpt
Mutations in growth signaling pathways extend life span, as well as protect against age-dependent DNA damage in yeast and decrease insulin resistance and cancer in mice. To test their effect in humans, we monitored for 22 years Ecuadorian individuals who carry mutations in the growth hormone receptor (GHR) gene that lead to severe GHR and IGF-1 (insulin-like growth factor-1) deficiencies. We combined this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.