Article
Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer.
Cell - 17 Feb 2012
Murchison Elizabeth P, Schulz-Trieglaff Ole B, Ning Zemin, Alexandrov Ludmil B, Bauer Markus J, Fu Beiyuan, Hims Matthew, Ding Zhihao, Ivakhno Sergii, Stewart Caitlin, Ng Bee Ling, Wong Wendy, Aken Bronwen, White Simon, Alsop Amber, Becq Jennifer, Bignell Graham R, Cheetham R Keira, Cheng William, Connor Thomas R, Cox Anthony J, Feng Zhi-Ping, Gu Yong, Grocock Russell J, Harris Simon R, Khrebtukova Irina, Kingsbury Zoya, Kowarsky Mark, Kreiss Alexandre, Luo Shujun, Marshall John, McBride David J, Murray Lisa, Pearse Anne-Maree, Raine Keiran, Rasolonjatovo Isabelle, Shaw Richard, Tedder Philip, Tregidgo Carolyn, Vilella Albert J, Wedge David C, Woods Gregory M, Gormley Niall, Humphray Sean, Schroth Gary, Smith Geoffrey, Hall Kevin, Searle Stephen M J, Carter Nigel P, Papenfuss Anthony T, Futreal P Andrew, Campbell Peter J, Yang Fengtang, Bentley David R, Evers Dirk J, Stratton Michael R
Abstract excerpt
The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered due to a transmissible facial cancer spread by direct transfer of living cancer cells through biting. Here we describe the sequencing, assembly, and annotation of the Tasmanian devil genome and whole-genome sequences for two geographically distant subclones of the cancer. Genomic analysis suggests that the cancer first...
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