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Article

MNS1 Is Essential for Spermiogenesis and Motile Ciliary Functions in Mice

1 Mar 2012

Abstract excerpt

During spermiogenesis, haploid round spermatids undergo dramatic cell differentiation and morphogenesis to give rise to mature spermatozoa for fertilization, including nuclear elongation, chromatin remodeling, acrosome formation, and development of flagella. The molecular mechanisms underlining these fundamental processes remain poorly understood. Here, we report that MNS1, a coiled-coil protein of unknown...

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PMID: 22396656
DOI: 10.1371/journal.pgen.1002516

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