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Article

Limited significance of family history for presence of BRCA1 gene mutation in Polish breast and ovarian cancer cases.

Familial cancer - 1 Sept 2012

Brozek Izabela, Ratajska Magdalena, Piatkowska Magdalena, Kluska Anna, Balabas Aneta, Dabrowska Michalina, Nowakowska Dorota, Niwinska Anna, Rachtan Jadwiga, Steffen Jan, Limon Janusz

Abstract excerpt

It is estimated that about 5-10% of ovarian and 2-5% of all breast cancer patients are carriers of a germline BRCA1 or BRCA2 gene mutation. Most families with detected BRCA1 or BRCA2 gene mutation are qualified for molecular testing on the basis of family history of breast or ovarian cancers. The purpose of our study was to establish the frequency of positive family history of cancer in a series of Polish...

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Identifiers

PMID: 22395474
DOI: 10.1007/s10689-012-9519-5
PMCID: PMC3496543

Genes

BRCA1
BRCA2

Variants

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