Article
Hereditary ovarian cancer in Poland.
International journal of cancer - 10 Oct 2003
Menkiszak Janusz, Gronwald Jacek, Górski Bohdan, Jakubowska Anna, Huzarski Tomasz, Byrski Tomasz, Foszczyńska-Kłoda Małgorzata, Haus Olga, Janiszewska Hanna, Perkowska Magdalena, Brozek Izabela, Grzybowska Ewa, Zientek Helena, Góźdź Stanisław, Kozak-Klonowska Beata, Urbański Krzysztof, Miturski Roman, Kowalczyk Jerzy, Pluzańska Anna, Niepsuj Stanisław, Koc Jan, Szwiec Marek, Drosik Kazimierz, Mackiewicz Andrzej, Lamperska Katarzyna, Strózyk Elwira, Godlewski Dariusz, Stawicka Małgorzata, Waśko Bernard, Bebenek Marek, Rozmiarek Andrzej, Rzepka-Górska Izabella, Narod Steven A, Lubiński Jan
Abstract excerpt
There is increasing evidence that hereditary factors play a greater role in ovarian cancer than in any of the other common cancers of adulthood. This is attributable, to a large extent, to a high frequency of mutations in the BRCA1 or BRCA2 genes. In Poland, 3 common founder mutations in BRCA1 account for the majority of families with identified BRCA mutations. Our study was conducted in order to estimate the...
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