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Article

A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma.

Cancer research - 1 May 2012

Yee Karen S, Grochola Lukasz, Hamilton Garth, Grawenda Anna, Bond Elisabeth E, Taubert Helge, Wurl Peter, Bond Gareth L, O'Neill Eric

Abstract excerpt

RASSF1A (Ras association domain containing family 1A), a tumor suppressor gene that is frequently inactivated in human cancers, is phosphorylated by ataxia telangiectasia mutated (ATM) on Ser131 upon DNA damage, leading to activation of a p73-dependent apoptotic response. A single-nucleotide polymorphism located in the region of the key ATM activation site of RASSF1A predicts the conversion of alanine (encoded by...

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Identifiers

PMID: 22389451
DOI: 10.1158/0008-5472.CAN-11-2906
PMCID: PMC4861210

Genes

ATM

Variants

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