Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm.

doi:10.1016/j.cell.2012.02.028

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Article

Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm.

Cell - 2 Mar 2012

Hou Yong, Song Luting, Zhu Ping, Zhang Bo, Tao Ye, Xu Xun, Li Fuqiang, Wu Kui, Liang Jie, Shao Di, Wu Hanjie, Ye Xiaofei, Ye Chen, Wu Renhua, Jian Min, Chen Yan, Xie Wei, Zhang Ruren, Chen Lei, Liu Xin, Yao Xiaotian, Zheng Hancheng, Yu Chang, Li Qibin, Gong Zhuolin, Mao Mao, Yang Xu, Yang Lin, Li Jingxiang, Wang Wen, Lu Zuhong, Gu Ning, Laurie Goodman, Bolund Lars, Kristiansen Karsten, Wang Jian, Yang Huanming, Li Yingrui, Zhang Xiuqing, Wang Jun

Abstract excerpt

Tumor heterogeneity presents a challenge for inferring clonal evolution and driver gene identification. Here, we describe a method for analyzing the cancer genome at a single-cell nucleotide level. To perform our analyses, we first devised and validated a high-throughput whole-genome single-cell sequencing method using two lymphoblastoid cell line single cells. We then carried out whole-exome single-cell...

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Identifiers

PMID: 22385957
DOI: 10.1016/j.cell.2012.02.028

Genes

JAK2
NTRK1
SESN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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