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Article

Noninvasive prediction of BRAF V600E mutation status of pleomorphic xanthoastrocytomas with MRI morphologic features and diffusion-weighted imaging.

BMC cancer - 19 Aug 2024

Yan Jing, Guo Cuiping, Zheng Hongwei, Li Yinhua, Duan Mengjiao, Zhang Chaoli, Cui Li, Lv Xiaofei, Fu Gui, Cheng Jingliang

Abstract excerpt

OBJECTIVES: Seeking a noninvasive predictor for BRAF V600E mutation status of pleomorphic xanthoastrocytomas (PXAs) is essential for their prognoses and therapeutic use of BRAF inhibitors. We aimed to noninvasively diagnose BRAF V600E-mutated PXAs using MRI morphologic, DWI and clinical parameters. METHODS: The clinical findings, anatomical MRI characteristics, and diffusion parameters of 36 pathologically...

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PMID: 39160463
DOI: 10.1186/s12885-024-12713-9
PMCID: PMC11331820

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