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Article

Purification and characterization of wild-type and mutant TK1 type kinases from Caenorhabditis elegans.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2006

Skovgaard T, Munch-Petersen B

Abstract excerpt

Caenorhabditis elegans has a single deoxynucleoside kinase-like gene. The sequence is similar to that of human TK1, but besides accepting thymidine as a substrate, the C. elegans TK1 (CeTK1) also phosphorylates deoxyguanosine. In contrast to human TK1, the CeTK1 exclusively exists as a dimer with a molecular mass of approximately 60 kDa, even if incubated with ATP. Incubation with ATP induces a transition into a...

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PMID: 17065083
DOI: 10.1080/15257770600894410

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