Article
Genetic diversity of EBV-encoded LMP1 in the Swiss HIV Cohort Study and implication for NF-Κb activation.
PloS one - 1 Jan 2012
Zuercher Emilie, Butticaz Christophe, Wyniger Josiane, Martinez Raquel, Battegay Manuel, Boffi El Amari Emmanuelle, Dang Thanh, Egger Jean-François, Fehr Jan, Mueller-Garamvögyi Esther, Parini Andrea, Schaefer Stephan C, Schoeni-Affolter Franziska, Thurnheer Christine, Tinguely Marianne, Telenti Amalio, Rothenberger Sylvia
Abstract excerpt
Epstein-Barr virus (EBV) is associated with several types of cancers including Hodgkin's lymphoma (HL) and nasopharyngeal carcinoma (NPC). EBV-encoded latent membrane protein 1 (LMP1), a multifunctional oncoprotein, is a powerful activator of the transcription factor NF-κB, a property that is ess...
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